Downregulation of lengthy noncoding RNA SNHG6 rescued propofol-induced

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1bp1

A novel platform to speed up antimicrobial susceptibility testing in Neisseria gonorrhoeae utilizing RNA signatures

The rise of antimicrobial-resistant pathogens could be attributed to the shortage of a speedy pathogen identification (ID) or antimicrobial susceptibility testing (AST), leading to delayed therapeutic choices on the point-of-care. Gonorrhea is often empirically handled with no AST outcomes obtainable earlier than therapy, thus contributing to the speedy rise in drug resistance.

Herein we current a speedy AST platform utilizing RNA signatures for Neisseria gonorrhoeae (NG). RNA-seq adopted by bioinformatic instruments had been utilized to discover potential markers within the transcriptome profile of NG upon minutes of azithromycin publicity. Validation of candidate markers utilizing qRT-PCR confirmed that two markers (arsR (NGO1562) and rpsO) can ship correct AST outcomes throughout 14 examined isolates.

Additional validation of our susceptibility threshold compared to MIC throughout 64 extra isolates confirmed the reliability of our platform. Our RNA markers mixed with rising molecular point-of-care programs has the potential to significantly speed up each ID and AST to tell therapy.

1bp1
1bp1

BDNF (human)

TP2069-10mg 10mg Ask for price
Description: BDNF (human)

BDNF (human)

TP2069-1g 1g Ask for price
Description: BDNF (human)

BDNF (human)

TP2069-1mg 1mg Ask for price
Description: BDNF (human)

BDNF (human)

TP2069-50mg 50mg Ask for price
Description: BDNF (human)

BDNF (human)

TP2069-5mg 5mg Ask for price
Description: BDNF (human)

BDNF (Human)

MBS5789515-INQUIRE INQUIRE Ask for price

BDNF, Human

MBS8575292-0005mg 0.005mg
EUR 245

BDNF, Human

MBS8575292-5x0005mg 5x0.005mg
EUR 940

Anti-Human BDNF Antibody

101-M138 100 µg
EUR 399
Description: BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa homodimer of two 119 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.

Anti-Human BDNF Antibody

101-M139 100 µg
EUR 399
Description: BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa homodimer of two 119 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.

Anti-Human BDNF Antibody

101-M229 100 µg
EUR 399
Description: Brain-derived neurotrophic factor (BDNF) is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous system. The neurotrophin family comprises at least four proteins including NGF, BDNF, NT3, and NT4/ 5. These secreted cytokines are synthesized as prepropeptides that are proteolytically processed to generate the mature proteins. All neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds and all share approximately 55% sequence identity at the amino acid level. Similarly to NGF, bioactive BDNF is predicted to be a noncovalently linked homodimer. BDNF cDNA encodes a 247 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature BDNF. The amino acid sequence of mature BDNF is identical in all mammals examined. High levels of expression of BDNF have been detected in the hippocampus, cerebellum, fetal eye, and placenta. In addition, low levels of BDNF expression are also found in the pituitary gland, spinal cord, heart, lung, and skeletal muscle. BDNF binds with high affinity and specifically activates the TrkB tyrosine kinase receptor.

Anti-Human BDNF Antibody

102-P02 100 µg
EUR 245.7
Description: BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa homodimer of two 119 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.

Anti-Human BDNF Antibody

MBS1569902-01mg 0.1mg
EUR 375

Anti-Human BDNF Antibody

MBS1569902-5x01mg 5x0.1mg
EUR 1390

Antibody for Human BDNF

SPC-703D-A565 0.1mg
EUR 480
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to ATTO 565.

Antibody for Human BDNF

SPC-703D-A633 0.1mg
EUR 480
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to ATTO 633.

Antibody for Human BDNF

SPC-703D-A655 0.1mg
EUR 480
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to ATTO 655.

Antibody for Human BDNF

SPC-703D-A680 0.1mg
EUR 480
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to ATTO 680.

Antibody for Human BDNF

SPC-703D-A700 0.1mg
EUR 480
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to ATTO 700.

Antibody for Human BDNF

SPC-703D-APCCY7 0.1mg
EUR 565.2
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to APC/Cy7.

Antibody for Human BDNF

SPC-703D-DY350 0.1mg
EUR 496.8
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Dylight 350.

Antibody for Human BDNF

SPC-703D-DY405 0.1mg
EUR 483.6
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Dylight 405.

Antibody for Human BDNF

SPC-703D-DY488 0.1mg
EUR 471.6
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Dylight 488.

Antibody for Human BDNF

SPC-703D-DY594 0.1mg
EUR 474
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Dylight 594.

Antibody for Human BDNF

SPC-703D-DY633 0.1mg
EUR 468
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Dylight 633.

Antibody for Human BDNF

SPC-703D-P594 0.1mg
EUR 488.4
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to PE/ATTO 594.

Antibody for Human BDNF

SPC-703D-STR 0.1mg
EUR 477.6
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Streptavidin.

Rabbit Anti Human BDNF Monoclonal Clone BEH-2

IRBAHUBDNFBEH2C100UL each
EUR 496
Description: Rabbit Anti Human BDNF Monoclonal Clone BEH-2

BDNF siRNA (Human)

MBS8230608-15nmol 15nmol
EUR 405

BDNF siRNA (Human)

MBS8230608-30nmol 30nmol
EUR 565

BDNF siRNA (Human)

MBS8230608-5x30nmol 5x30nmol
EUR 2450

Recombinant Human BDNF

Z100065 10 µg
EUR 235
Description: BDNF is found in neurons of the central nervous system. It is expressed predominantly in hippocampus, cortex, and synapses of the basal forebrain. The biological activity of BDNF is mediated by a receptor that belongs to the trk family of receptors encoding a tyrosine-specific protein kinase. BDNF only binds weakly to the gp140trk receptor (to which NGF binds with high affinity), and it binds to the NGF receptor known as LNGFR. BDNF selectively supports the survival of primary sensory neurons and retinal ganglia. The factor supports survival and differentiation of certain cholinergic neurons and also some dopaminergic neurons in vitro. BDNF does not appear to act on sympathetic ganglia. In specific neurons of the central nervous system located in the hippocampus and the cortex the synthesis of BDNF is influenced by neuronal activity either positively (glutamate transmitter system) or negatively (GABA transmitter system).

Recombinant Human BDNF

Z100069 1.0 mg
EUR 6900
Description: BDNF is found in neurons of the central nervous system. It is expressed predominantly in hippocampus, cortex, and synapses of the basal forebrain. The biological activity of BDNF is mediated by a receptor that belongs to the trk family of receptors encoding a tyrosine-specific protein kinase. BDNF only binds weakly to the gp140trk receptor (to which NGF binds with high affinity), and it binds to the NGF receptor known as LNGFR. BDNF selectively supports the survival of primary sensory neurons and retinal ganglia. The factor supports survival and differentiation of certain cholinergic neurons and also some dopaminergic neurons in vitro. BDNF does not appear to act on sympathetic ganglia. In specific neurons of the central nervous system located in the hippocampus and the cortex the synthesis of BDNF is influenced by neuronal activity either positively (glutamate transmitter system) or negatively (GABA transmitter system).

RECOMBINANT HUMAN BDNF

GWB-DE906C 0.01 mg Ask for price

Recombinant Human BDNF

P0449 100ug
EUR 626.83
Description: Recombinant Human protein for BDNF

Recombinant Human BDNF

MBS7608556-005mg 0.05mg
EUR 345

Recombinant Human BDNF

MBS7608556-02mg 0.2mg
EUR 635

Recombinant Human BDNF

MBS7608556-1mg 1mg
EUR 1800

Recombinant Human BDNF

MBS7608556-5x1mg 5x1mg
EUR 6955

Recombinant Human BDNF

MBS7609632-005mg 0.05mg
EUR 345

Recombinant Human BDNF

MBS7609632-02mg 0.2mg
EUR 635

Recombinant Human BDNF

MBS7609632-1mg 1mg
EUR 1800

Recombinant Human BDNF

MBS7609632-5x1mg 5x1mg
EUR 6955

RECOMBINANT HUMAN BDNF

MBS232457-001mg 0.01mg
EUR 520

RECOMBINANT HUMAN BDNF

MBS232457-5x001mg 5x0.01mg
EUR 2160

Recombinant Human BDNF

MBS4159636-001mg 0.01mg
EUR 385

Recombinant Human BDNF

MBS4159636-1mg 1(mg)
EUR 7935

anti- BDNF antibody

FNab10014 100µg
EUR 658.5
Description: Antibody raised against BDNF

anti- BDNF antibody

FNab00859 100µg
EUR 606.3
Description: Antibody raised against BDNF

Rabbit anti-Homo sapiens (Human) BDNF Polyclonal Antibody

MBS7138282-INQUIRE INQUIRE Ask for price

BDNF, human recombinant

4004-10 each
EUR 333.6

BDNF, human recombinant

4004-1000 each
EUR 6571.2

BDNF, human recombinant

4004-250 each
EUR 2461.2

BDNF, human recombinant

4004-50 each
EUR 816

BDNF, human recombinant

P1007-.01 10 µg
EUR 261
Description: BDNF, expressed in E. coli, a potent neurotrophic factor.

BDNF, human recombinant

P1007-.05 50 µg
EUR 658
Description: BDNF, expressed in E. coli, a potent neurotrophic factor.

BDNF, human recombinant

P1007-.25 250 µg
EUR 2050
Description: BDNF, expressed in E. coli, a potent neurotrophic factor.

BDNF, human recombinant

P1007-1 1 mg
EUR 5530
Description: BDNF, expressed in E. coli, a potent neurotrophic factor.

BDNF, human recombinant

P1007-.1 100ug
EUR 900.8
Description: Neurotrophins|Brain-Derived Neurotrophic Factor

Mouse Monoclonal anti-Human BDNF

hAP-0109 100ug
EUR 250

Mouse Monoclonal anti-Human BDNF

hAP-0109A 100ug
EUR 250

Mouse Monoclonal anti-Human BDNF

hAP-0109B 100ug
EUR 250

InVivoMAb Anti-Human BDNF (Iv0093)

MBS1570123-01mg 0.1mg
EUR 405

InVivoMAb Anti-Human BDNF (Iv0093)

MBS1570123-5x01mg 5x0.1mg
EUR 1520

Human BDNF ELISA Kit

E16HE0041 96T
EUR 833.33

Human BDNF ELISA Kit

EHB0036 96Tests
EUR 625.2

Human BDNF ELISA Kit

E28L0224 96T
EUR 666.67

Human BDNF ELISA Kit

EK5126 96 tests
EUR 449

Human BDNF ELISA Kit

55R-1556 1 kit
EUR 615
Description: ELISA kit for detection of BDNF in the research laboratory

Human BDNF ELISA Kit

ELA-E0011h 96tests
EUR 696

Human BDNF ELISA KIT

EF006120 96tests
EUR 566

Human BDNF ELISA Kit

GWB-SKR197 96 Tests Ask for price

Human BDNF ELISA Kit

GWB-ZZD022 1x96 well plate Ask for price

Human BDNF ELISA kit

LF-EK50005 1×96T
EUR 777.6

Human BDNF ELISA Kit

STJ150202 1 kit
EUR 494.4
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of BDNF in human serum, plasma and other biological fluids

Human BDNF ELISA Kit

MBS824804-5x96Tests 5x96Tests
EUR 2755

Human BDNF ELISA Kit

MBS824804-96Tests 96Tests
EUR 620

Human BDNF ELISA Kit

MBS9135790-5x96Tests 5x96Tests
EUR 2615

Human BDNF ELISA Kit

MBS9135790-96Tests 96Tests
EUR 570

Rabbit Anti-Human BDNF Polyclonal

SPC-703D 0.1mg
EUR 331
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is unconjugated.

Rabbit Anti-Human BDNF Polyclonal

SPC-703D-A390 0.1mg
EUR 385
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to ATTO 390.

Rabbit Anti-Human BDNF Polyclonal

SPC-703D-A488 0.1mg
EUR 384
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to ATTO 488.

Rabbit Anti-Human BDNF Polyclonal

SPC-703D-A594 0.1mg
EUR 384
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to ATTO 594.

Rabbit Anti-Human BDNF Polyclonal

SPC-703D-ALP 0.1mg
EUR 377
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Alkaline Phosphatase.

Rabbit Anti-Human BDNF Polyclonal

SPC-703D-APC 0.1mg
EUR 383
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to APC .

Rabbit Anti-Human BDNF Polyclonal

SPC-703D-BI 0.1mg
EUR 380
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Biotin.

Rabbit Anti-Human BDNF Polyclonal

SPC-703D-FITC 0.1mg
EUR 375
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to FITC.

Rabbit Anti-Human BDNF Polyclonal

SPC-703D-HRP 0.1mg
EUR 371
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to HRP.

Rabbit Anti-Human BDNF Polyclonal

SPC-703D-PCP 0.1mg
EUR 383
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to PerCP.

Rabbit Anti-Human BDNF Polyclonal

SPC-703D-RPE 0.1mg
EUR 381
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to RPE .

Rabbit Anti-Human BDNF Polyclonal

SPC-703S 0.012mg
EUR 44
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is unconjugated.

Rabbit Anti-Human BDNF Polyclonal

MBS807457-01mg 0.1mg
EUR 565

Rabbit Anti-Human BDNF Polyclonal

MBS807457-5x01mg 5x0.1mg
EUR 2000

Rabbit Anti-Human BDNF Polyclonal

MBS807483-01mg 0.1mg
EUR 520

Rabbit Anti-Human BDNF Polyclonal

MBS807483-5x01mg 5x0.1mg
EUR 1785

Rabbit Anti-Human BDNF Polyclonal

MBS807487-01mg 0.1mg
EUR 570

Rabbit Anti-Human BDNF Polyclonal

MBS807487-5x01mg 5x0.1mg
EUR 2025

Rabbit Anti-Human BDNF Polyclonal

MBS807503-01mg 0.1mg
EUR 570

Rabbit Anti-Human BDNF Polyclonal

MBS807503-5x01mg 5x0.1mg
EUR 2025

Rabbit Anti-Human BDNF Polyclonal

MBS807553-01mg 0.1mg
EUR 570

Rabbit Anti-Human BDNF Polyclonal

MBS807553-5x01mg 5x0.1mg
EUR 2020

Rabbit Anti-Human BDNF Polyclonal

MBS807570-01mg 0.1mg
EUR 555

Rabbit Anti-Human BDNF Polyclonal

MBS807570-5x01mg 5x0.1mg
EUR 1970

Rabbit Anti-Human BDNF Polyclonal

MBS807630-01mg 0.1mg
EUR 560

Rabbit Anti-Human BDNF Polyclonal

MBS807630-5x01mg 5x0.1mg
EUR 1990

Rabbit Anti-Human BDNF Polyclonal

MBS807632-01mg 0.1mg
EUR 565

Rabbit Anti-Human BDNF Polyclonal

MBS807632-5x01mg 5x0.1mg
EUR 2010

Rabbit Anti-Human BDNF Polyclonal

MBS807648-01mg 0.1mg
EUR 565

Rabbit Anti-Human BDNF Polyclonal

MBS807648-5x01mg 5x0.1mg
EUR 2005

Rabbit Anti-Human BDNF Polyclonal

MBS807679-01mg 0.1mg
EUR 570

Rabbit Anti-Human BDNF Polyclonal

MBS807679-5x01mg 5x0.1mg
EUR 2030

Human BDNF Antibody (Biotin Conjugate)

32507-05121 150 ug
EUR 315

Human BDNF shRNA Plasmid

20-abx950425
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

BDNF (Human) ELISA Kit

EKA52013-5x96T 5x96T Ask for price

BDNF (Human) ELISA Kit

EKA52013-96T 96T
EUR 446.9

BDNF (human) ELISA Kit

K4788-100 each
EUR 1070.4

BDNF Human ELISA Kit

MBS355324-5x96Tests 5x96Tests
EUR 2050

BDNF Human ELISA Kit

MBS355324-96Tests 96Tests
EUR 455

Human BDNF Protein Lysate

MBS137924-002mg 0.02mg
EUR 365

Human BDNF Protein Lysate

MBS137924-5x002mg 5x0.02mg
EUR 1410

Human BDNF Recombinant Protein

100-005 10 µg
EUR 196.35
Description: BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.

Human BDNF Recombinant Protein

100-005S 2 µg
EUR 92.4
Description: BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.

Recombinant Human BDNF Protein

E40KMP1488 20ug
EUR 495

Recombinant Human BDNF Protein

PROTP23560-3 10ug
EUR 380.4
Description: BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.

Recombinant Human BDNF Protein

RP00308 10 μg
EUR 265.2

Recombinant Human BDNF Protein

MBS8248602-001mg 0.01mg
EUR 295

Recombinant Human BDNF Protein

MBS8248602-005mg 0.05mg
EUR 690

Recombinant Human BDNF Protein

MBS8248602-05mg 0.5mg
EUR 2510

Recombinant Human BDNF Protein

MBS8248602-5x05mg 5x0.5mg
EUR 11220

Recombinant human BDNF Protein

MBS9144151-002mg 0.02mg
EUR 235

Recombinant human BDNF Protein

MBS9144151-005mg 0.05mg
EUR 320

Recombinant human BDNF Protein

MBS9144151-01mg 0.1mg
EUR 460

Recombinant human BDNF Protein

MBS9144151-5x01mg 5x0.1mg
EUR 1900

Recombinant Human BDNF protein

MBS1561130-005mg 0.05mg
EUR 320

Recombinant Human BDNF protein

MBS1561130-01mg 0.1mg
EUR 410

Recombinant Human BDNF protein

MBS1561130-5x01mg 5x0.1mg
EUR 1520

Recombinant human BDNF protein

MBS5308533-01mg 0.1mg
EUR 690

Recombinant human BDNF protein

MBS5308533-5x01mg 5x0.1mg
EUR 2960

Anti-rh BDNF Antibody

Y075081 100 µl
EUR 535

Anti-pro BDNF antibody

STJ13100047 100 µl
EUR 512.4

Anti-pro BDNF antibody

STJ13100048 500 µg
EUR 512.4

Anti-pro BDNF antibody

STJ13100063 100 µl
EUR 512.4

Anti-mature BDNF antibody

STJ13100056 100 µl
EUR 512.4

Anti-mature BDNF antibody

STJ13100057 100 µl
EUR 512.4

Anti-mature BDNF antibody

STJ13100064 100 µl
EUR 512.4

BDNF (NM_170735) Human Over-expression Lysate

LS000627 100ug
EUR 628
Description: Transient overexpression lysate of brain-derived neurotrophic factor (BDNF), transcript variant 1

Human BDNF ELISA kit (4X96T)

LF-EK50006 4×96T
EUR 2641.2

Human BDNF Quick ELISA Kit

MBS1753904-5x96StripWells 5x96-Strip-Wells
EUR 2755

Human BDNF Quick ELISA Kit

MBS1753904-96StripWells 96-Strip-Wells
EUR 600

Mouse Monoclonal anti-Human BDNF Antibody

xAP-0037 100ug
EUR 280

Anti-Human BDNF Rabbit Polyclonal Antibody

TA328268 100 µg Ask for price

Human BDNF knockout cell line

ABC-KH1413 1 vial Ask for price
Description: Human BDNF knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human BDNF PicoKine ELISA Kit

MBS176010-5x96StripWells 5x96-Strip-Wells
EUR 2295

Human BDNF PicoKine ELISA Kit

MBS176010-96StripWells 96-Strip-Wells
EUR 500

Goat Polyclonal to Human BDNF

MBS243012-005mg 0.05mg
EUR 595

Goat Polyclonal to Human BDNF

MBS243012-5x005mg 5x0.05mg
EUR 2500

Human BDNF knockdown cell line

ABC-KD1413 1 vial Ask for price
Description: Human BDNF knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human BDNF Protein Lysate 20ug

IHUBDNFPLLY20UG each
EUR 213
Description: Human BDNF Protein Lysate 20ug

BDNF ORF Vector (Human) (pORF)

ORF000995 1.0 ug DNA
EUR 114

Downregulation of lengthy noncoding RNA SNHG6 rescued propofol-induced cytotoxicity in human induced pluripotent stem cell-derived cardiomyocytes

 Background: Propofol (PPF) overdose is a uncommon however deadly situation, which can result in extreme cardiac failure. On this research, we established an in vitro PPF-induced cardiac cytotoxicity mannequin, and examine the purposeful function of lengthy non-coding RNA (lncRNA) small nucleolar RNA host gene 6 (SNHG6).

Strategies: Human induced pluripotent stem cell-derived cardiomyocytes (HiPSC-CMs) had been uncovered to PPF in vitro. PPF-induced cytotoxic results had been measured. PPF-induced SNHG6 expression change in HiPSC-CMs had been monitored by qRT-PCR. SNHG6 was downregulated in HiPSC-CMs to look at its function in PPF-induced cardiac cytotoxicity.

The expression of competing endogenous RNA (ceRNA) candidate of SNHG6, human microRNA-186-5p (hsa-miR-186-5p) was additionally investigated in PPF-exposed HiPSC-CMs. Capabilities of hsa-miR-186-5p had been additional investigated in PPF-exposed and SNHG6-downregulated HiPSC-CMs.

Outcomes: PPF induced important cytotoxicity, in addition to SNHG6 upregulation in HiPSC-CMs. SNHG6 downregulation had rescuing results on PPF-induced cardiac cytotoxicity. Twin-luciferase exercise assay confirmed that hsa-miR-186-5p was the ceRNA candidate of SNHG6. QRT-PCR confirmed hsa-miR-186-5p expression was reversely correlated with SNHG6 in PPF-exposed HiPSC-CMs. Suppressing hsa-miR-186-5p lowered the rescuing results of SNHG6-downregulation on PPF-induced cardiac cytotoxicity.

Conclusions: SNHG6/hsa-miR-186-5p can modulate PPF-induced cardiac cytotoxicity in HiPSC-CMs, and thus could also be a future drug goal to forestall PPF infusion syndrome.

Round RNA GLIS2 promotes colorectal most cancers cell motility through activation of the NF-κB pathway 

Round RNAs (circRNAs) are a newly found kind of organic molecule that belongs to the noncoding RNA household. Plentiful proof has proven that circRNAs are concerned within the development of varied cancers. Nevertheless, the actual features of circRNAs in colorectal most cancers (CRC) stay elusive. On this research, we investigated the differentially expressed circRNAs in three pairs of most cancers tissue and adjoining regular tissue of CRC.

We revealed that circGLIS2 expression was greater in CRC tissue and cell traces. Acquire-and-loss perform assays confirmed that circGLIS2 was concerned within the regulation of cell migration. Furthermore, overexpressing circGLIS2 in CRC cells activated the NF-κB pathway and induced pro-inflammatory chemokine manufacturing, which evoked tumor-associated irritation by recruiting leukocytes. In flip, when the most cancers cells had been uncovered to the supernatant of circGLIS2 overexpressed most cancers cells, they had been endowed with the flexibility of migration and chemokines manufacturing.

Moreover, the rescue assay confirmed that circGLIS2 activated NF-κB signaling and promoted cell migration by sponging miR-671. General, our research reveals that circGLIS2, performing as a possible oncogene, maintains the irregular activation state of the NF-κB signaling pathway through the miR-671 sponge mechanism in CRC cells. This research offers a scientific foundation for focusing on circGLIS2 in colorectal most cancers interventions.

The RNA binding protein FMR1 controls selective exosomal miRNA cargo loading throughout irritation 

  • Cells reply to inflammatory illness states by releasing exosomes containing extremely particular protein and RNA cargos, however how irritation alters cargo specificity and secretion of exosomes is unknown.
  • We present that will increase in exosome secretion induced by both viral an infection or LPS/ATP publicity consequence from inflammasome activation and subsequent caspase-1-dependent cleavage of the trafficking adaptor protein RILP.
  • This cleaved type of RILP promotes the motion of multivesicular our bodies towards the cell periphery and induces selective exosomal miRNA cargo loading. We’ve got recognized a standard brief sequence motif current in miRNAs which are selectively loaded into exosomes after RILP cleavage.
  • This motif binds the RNA binding protein FMR1 and directs miRNA loading into exosomes through interplay with elements of the ESCRT (endosomal sorting advanced required for transport) pathway. These outcomes point out that inflammasome-mediated RILP cleavage, and sequence-specific interactions between miRNAs and FMR1, play a big function in exosome cargo loading and enhanced secretion throughout mobile inflammatory responses.

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