Downregulation of lengthy noncoding RNA SNHG6 rescued propofol-induced

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1bp1

A novel platform to speed up antimicrobial susceptibility testing in Neisseria gonorrhoeae utilizing RNA signatures

The rise of antimicrobial-resistant pathogens could be attributed to the shortage of a speedy pathogen identification (ID) or antimicrobial susceptibility testing (AST), leading to delayed therapeutic choices on the point-of-care. Gonorrhea is often empirically handled with no AST outcomes obtainable earlier than therapy, thus contributing to the speedy rise in drug resistance.

Herein we current a speedy AST platform utilizing RNA signatures for Neisseria gonorrhoeae (NG). RNA-seq adopted by bioinformatic instruments had been utilized to discover potential markers within the transcriptome profile of NG upon minutes of azithromycin publicity. Validation of candidate markers utilizing qRT-PCR confirmed that two markers (arsR (NGO1562) and rpsO) can ship correct AST outcomes throughout 14 examined isolates.

Additional validation of our susceptibility threshold compared to MIC throughout 64 extra isolates confirmed the reliability of our platform. Our RNA markers mixed with rising molecular point-of-care programs has the potential to significantly speed up each ID and AST to tell therapy.

1bp1
1bp1

Anti-Human BDNF Antibody

101-M138 100 µg
EUR 399
Description: BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa homodimer of two 119 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.

Anti-Human BDNF Antibody

101-M139 100 µg
EUR 399
Description: BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa homodimer of two 119 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.

Anti-Human BDNF Antibody

101-M229 100 µg
EUR 399
Description: Brain-derived neurotrophic factor (BDNF) is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous system. The neurotrophin family comprises at least four proteins including NGF, BDNF, NT3, and NT4/ 5. These secreted cytokines are synthesized as prepropeptides that are proteolytically processed to generate the mature proteins. All neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds and all share approximately 55% sequence identity at the amino acid level. Similarly to NGF, bioactive BDNF is predicted to be a noncovalently linked homodimer. BDNF cDNA encodes a 247 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature BDNF. The amino acid sequence of mature BDNF is identical in all mammals examined. High levels of expression of BDNF have been detected in the hippocampus, cerebellum, fetal eye, and placenta. In addition, low levels of BDNF expression are also found in the pituitary gland, spinal cord, heart, lung, and skeletal muscle. BDNF binds with high affinity and specifically activates the TrkB tyrosine kinase receptor.

Anti-Human BDNF Antibody

102-P02 100 µg
EUR 245.7
Description: BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa homodimer of two 119 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.

anti- BDNF antibody

FNab10014 100µg
EUR 658.5
Description: Antibody raised against BDNF

anti- BDNF antibody

FNab00859 100µg
EUR 606.3
Description: Antibody raised against BDNF

Antibody for Human BDNF

SPC-703D-A565 0.1mg
EUR 480
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to ATTO 565.

Antibody for Human BDNF

SPC-703D-A633 0.1mg
EUR 480
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to ATTO 633.

Antibody for Human BDNF

SPC-703D-A655 0.1mg
EUR 480
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to ATTO 655.

Antibody for Human BDNF

SPC-703D-A680 0.1mg
EUR 480
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to ATTO 680.

Antibody for Human BDNF

SPC-703D-A700 0.1mg
EUR 480
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to ATTO 700.

Antibody for Human BDNF

SPC-703D-APCCY7 0.1mg
EUR 565.2
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to APC/Cy7.

Antibody for Human BDNF

SPC-703D-DY350 0.1mg
EUR 496.8
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Dylight 350.

Antibody for Human BDNF

SPC-703D-DY405 0.1mg
EUR 483.6
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Dylight 405.

Antibody for Human BDNF

SPC-703D-DY488 0.1mg
EUR 471.6
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Dylight 488.

Antibody for Human BDNF

SPC-703D-DY594 0.1mg
EUR 474
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Dylight 594.

Antibody for Human BDNF

SPC-703D-DY633 0.1mg
EUR 468
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Dylight 633.

Antibody for Human BDNF

SPC-703D-P594 0.1mg
EUR 488.4
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to PE/ATTO 594.

Antibody for Human BDNF

SPC-703D-STR 0.1mg
EUR 477.6
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Streptavidin.

Rabbit Anti Human BDNF Monoclonal Clone BEH-2

IRBAHUBDNFBEH2C100UL each
EUR 496
Description: Rabbit Anti Human BDNF Monoclonal Clone BEH-2

RECOMBINANT HUMAN BDNF

GWB-DE906C 0.01 mg Ask for price

Recombinant Human BDNF

P0449 100ug
EUR 626.83
Description: Recombinant Human protein for BDNF

Recombinant Human BDNF

Z100065 10 µg
EUR 235
Description: BDNF is found in neurons of the central nervous system. It is expressed predominantly in hippocampus, cortex, and synapses of the basal forebrain. The biological activity of BDNF is mediated by a receptor that belongs to the trk family of receptors encoding a tyrosine-specific protein kinase. BDNF only binds weakly to the gp140trk receptor (to which NGF binds with high affinity), and it binds to the NGF receptor known as LNGFR. BDNF selectively supports the survival of primary sensory neurons and retinal ganglia. The factor supports survival and differentiation of certain cholinergic neurons and also some dopaminergic neurons in vitro. BDNF does not appear to act on sympathetic ganglia. In specific neurons of the central nervous system located in the hippocampus and the cortex the synthesis of BDNF is influenced by neuronal activity either positively (glutamate transmitter system) or negatively (GABA transmitter system).

Recombinant Human BDNF

Z100069 1.0 mg
EUR 6900
Description: BDNF is found in neurons of the central nervous system. It is expressed predominantly in hippocampus, cortex, and synapses of the basal forebrain. The biological activity of BDNF is mediated by a receptor that belongs to the trk family of receptors encoding a tyrosine-specific protein kinase. BDNF only binds weakly to the gp140trk receptor (to which NGF binds with high affinity), and it binds to the NGF receptor known as LNGFR. BDNF selectively supports the survival of primary sensory neurons and retinal ganglia. The factor supports survival and differentiation of certain cholinergic neurons and also some dopaminergic neurons in vitro. BDNF does not appear to act on sympathetic ganglia. In specific neurons of the central nervous system located in the hippocampus and the cortex the synthesis of BDNF is influenced by neuronal activity either positively (glutamate transmitter system) or negatively (GABA transmitter system).

Mouse Monoclonal anti-Human BDNF

hAP-0109 100ug
EUR 250

Mouse Monoclonal anti-Human BDNF

hAP-0109A 100ug
EUR 250

Mouse Monoclonal anti-Human BDNF

hAP-0109B 100ug
EUR 250

Rabbit Anti-Human BDNF Polyclonal

SPC-703D 0.1mg
EUR 331
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is unconjugated.

Rabbit Anti-Human BDNF Polyclonal

SPC-703D-A390 0.1mg
EUR 385
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to ATTO 390.

Rabbit Anti-Human BDNF Polyclonal

SPC-703D-A488 0.1mg
EUR 384
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to ATTO 488.

Rabbit Anti-Human BDNF Polyclonal

SPC-703D-A594 0.1mg
EUR 384
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to ATTO 594.

Rabbit Anti-Human BDNF Polyclonal

SPC-703D-ALP 0.1mg
EUR 377
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Alkaline Phosphatase.

Rabbit Anti-Human BDNF Polyclonal

SPC-703D-APC 0.1mg
EUR 383
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to APC .

Rabbit Anti-Human BDNF Polyclonal

SPC-703D-BI 0.1mg
EUR 380
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Biotin.

Rabbit Anti-Human BDNF Polyclonal

SPC-703D-FITC 0.1mg
EUR 375
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to FITC.

Rabbit Anti-Human BDNF Polyclonal

SPC-703D-HRP 0.1mg
EUR 371
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to HRP.

Rabbit Anti-Human BDNF Polyclonal

SPC-703D-PCP 0.1mg
EUR 383
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to PerCP.

Rabbit Anti-Human BDNF Polyclonal

SPC-703D-RPE 0.1mg
EUR 381
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to RPE .

Rabbit Anti-Human BDNF Polyclonal

SPC-703S 0.012mg
EUR 44
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is unconjugated.

Anti-rh BDNF Antibody

Y075081 100 µl
EUR 535

BDNF, human recombinant

4004-10 each
EUR 333.6

BDNF, human recombinant

4004-1000 each
EUR 6571.2

BDNF, human recombinant

4004-250 each
EUR 2461.2

BDNF, human recombinant

4004-50 each
EUR 816

BDNF, human recombinant

P1007-.01 10 µg
EUR 261
Description: BDNF, expressed in E. coli, a potent neurotrophic factor.

BDNF, human recombinant

P1007-.05 50 µg
EUR 658
Description: BDNF, expressed in E. coli, a potent neurotrophic factor.

BDNF, human recombinant

P1007-.25 250 µg
EUR 2050
Description: BDNF, expressed in E. coli, a potent neurotrophic factor.

BDNF, human recombinant

P1007-1 1 mg
EUR 5530
Description: BDNF, expressed in E. coli, a potent neurotrophic factor.

Anti-pro BDNF antibody

STJ13100047 100 µl
EUR 512.4

Anti-pro BDNF antibody

STJ13100048 500 µg
EUR 512.4

Anti-pro BDNF antibody

STJ13100063 100 µl
EUR 512.4

Anti-mature BDNF antibody

STJ13100056 100 µl
EUR 512.4

Anti-mature BDNF antibody

STJ13100057 100 µl
EUR 512.4

Anti-mature BDNF antibody

STJ13100064 100 µl
EUR 512.4

Human BDNF ELISA Kit

E16HE0041 96T
EUR 833.33

Human BDNF ELISA Kit

EHB0036 96Tests
EUR 625.2

Human BDNF ELISA Kit

ELA-E0011h 96 Tests
EUR 988.8

Human BDNF ELISA Kit

E28L0224 96T
EUR 666.67

Human BDNF ELISA Kit

EK5126 96 tests
EUR 449

Human BDNF ELISA Kit

55R-1556 1 kit
EUR 615
Description: ELISA kit for detection of BDNF in the research laboratory

Human BDNF ELISA Kit

GWB-SKR197 96 Tests Ask for price

Human BDNF ELISA Kit

GWB-ZZD022 1x96 well plate Ask for price

Human BDNF ELISA kit

LF-EK50005 1×96T
EUR 777.6

Human BDNF ELISA Kit

STJ150202 1 kit
EUR 494.4
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of BDNF in human serum, plasma and other biological fluids

BDNF ELISA KIT|Human

EF006120 96 Tests
EUR 826.8

BDNF (Human) ELISA Kit

EKA52013-5x96T 5x96T Ask for price

BDNF (Human) ELISA Kit

EKA52013-96T 96T
EUR 446.9

BDNF (human) ELISA Kit

K4788-100 each
EUR 1070.4

Human BDNF Antibody (Biotin Conjugate)

32507-05121 150 ug
EUR 315

Human BDNF shRNA Plasmid

20-abx950425
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

Mouse Monoclonal anti-Human BDNF Antibody

xAP-0037 100ug
EUR 280

Anti-Human BDNF Rabbit Polyclonal Antibody

TA328268 100 µg Ask for price

Human BDNF Recombinant Protein

100-005 10 µg
EUR 196.35
Description: BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.

Human BDNF Recombinant Protein

100-005S 2 µg
EUR 92.4
Description: BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.

Recombinant Human BDNF Protein

E40KMP1488 20ug
EUR 495

Recombinant Human BDNF Protein

PROTP23560-3 10ug
EUR 380.4
Description: BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.

Recombinant Human BDNF Protein

RP00308 10 μg
EUR 265.2

Human BDNF ELISA kit (4X96T)

LF-EK50006 4×96T
EUR 2641.2

Human BDNF knockout cell line

ABC-KH1413 1 vial Ask for price
Description: Human BDNF knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

BDNF/ Rat BDNF ELISA Kit

ELA-E0011r 96 Tests
EUR 1063.2

BDNF ORF Vector (Human) (pORF)

ORF000995 1.0 ug DNA
EUR 114

Human BDNF knockdown cell line

ABC-KD1413 1 vial Ask for price
Description: Human BDNF knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human BDNF Protein Lysate 20ug

IHUBDNFPLLY20UG each
EUR 213
Description: Human BDNF Protein Lysate 20ug

BDNF ELISA Kit (Human) (OKCD05621)

OKCD05621 96 Wells
EUR 746.4
Description: Description of target: BDNF is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression BDNF is reduced in both Alzheimer's and Huntington disease patients. BDNF may play a role in the regulation of stress response and in the biology of mood disorders.The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene, but the full-length nature of only some could be determined.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 12.1pg/mL

BDNF ELISA Kit (Human) (OKBB00127)

OKBB00127 96 Tests
EUR 606
Description: Description of target: BDNF and neurotrophin-3 (NT-3) are two recently cloned neurotrophic factors that are homologous to NGF. mRNA products of the BDNF and NT-3 genes are detected in the adult human brain, suggesting that these proteins are involved in the maintenance of the adult nervous system.1 BDNF and other neurotrophins are critically involved in long-term potentiation (LTP). BDNF-mediated LTP is induced postsynaptically.2 BDNF has trophic effects on serotonergic (5-HT) neurons in the central nervous system.3 BDNF has an essential maintenance function in the regulation of anxiety-related behavior and in food intake through central mediators in both the basal and fasted state.4 It plays a role in treating breathing disorders such as respiratory insufficiency after spinal injury.5 The mature form of BDNF is identical in all mammals examined, and the gene encoding human BDNF to chromosome 11, band p13. 6.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 2 pg/ml

Human BDNF Signaling Primer Library

HBDNF-I 1 set
EUR 657.6

OPSA11059-10UG - Human BDNF Protein

OPSA11059-10UG 10ug
EUR 469

BDNF Antibody

ABD6387 100 ug
EUR 525.6

BDNF antibody

10R-7738 500 ug
EUR 678
Description: Mouse monoclonal BDNF antibody

BDNF antibody

20R-BC001 50 ug Ask for price
Description: Chicken polyclonal BDNF antibody

BDNF antibody

20R-1770 100 ug
EUR 807.6
Description: Rabbit polyclonal BDNF antibody

BDNF Antibody

32263 100ul
EUR 439

BDNF Antibody

32263-100ul 100ul
EUR 302.4

BDNF Antibody

48503 100ul
EUR 429

BDNF Antibody

48503-100ul 100ul
EUR 399.6

BDNF Antibody

48503-50ul 50ul
EUR 286.8

BDNF Antibody

48755 100ul
EUR 499

BDNF Antibody

48755-100ul 100ul
EUR 399.6

BDNF Antibody

48755-50ul 50ul
EUR 286.8

BDNF Antibody

1-CSB-PA988388
  • Ask for price
  • Ask for price
  • 100ul
  • 50ul
Description: A polyclonal antibody against BDNF. Recognizes BDNF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:10000, IHC:1:30-1:150

BDNF Antibody

E10-30610 100ul
EUR 225
Description: Available in various conjugation types.

BDNF Antibody

DF6387 200ul
EUR 420

BDNF Antibody

DF6387-100ul 100ul
EUR 280

BDNF Antibody

DF6387-200ul 200ul
EUR 350

BDNF antibody

E39-10014 100ug/100ul
EUR 225
Description: Available in various conjugation types.

BDNF Antibody

E91307 100ul
EUR 255
Description: Available in various conjugation types.

Bdnf Antibody

E301089 100ug/200ul
EUR 275
Description: Available in various conjugation types.

BDNF Antibody

CAC11765-100ug 100ug
EUR 314

BDNF Antibody

CAC11765-50ug 50ug
EUR 199.2

BDNF antibody

CAF50446-100ug 100ug
EUR 338

BDNF antibody

CAF50510-100ug 100ug
EUR 312

BDNF Antibody

CAC07061-100ug 100ug
EUR 314

BDNF Antibody

CAC07061-50ug 50ug
EUR 199.2

Bdnf Antibody

CAC10423-100ug 100ug
EUR 314

Bdnf Antibody

CAC10423-50ug 50ug
EUR 199.2

BDNF antibody

70R-12244 100 ug
EUR 357
Description: Rabbit polyclonal BDNF antibody

BDNF antibody

70R-13697 100 ug
EUR 576
Description: Affinity purified polyclonal BDNF antibody

BDNF antibody

70R-15327 100 ug
EUR 303
Description: Rabbit polyclonal BDNF antibody

BDNF antibody

70R-15985 50 ul
EUR 289
Description: Rabbit polyclonal BDNF antibody

BDNF Antibody

5004-100 each
EUR 392.4

BDNF antibody

70R-6209 50 ug
EUR 467
Description: Rabbit polyclonal BDNF antibody raised against the middle region of BDNF

BDNF antibody

70R-BR012 50 ug
EUR 312
Description: Affinity purified Rabbit polyclonal BDNF antibody

BDNF Antibody

1-CSB-PA002655GA01HU
  • Ask for price
  • Ask for price
  • 150ul
  • 50ul
Description: A polyclonal antibody against BDNF. Recognizes BDNF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA

BDNF Antibody

1-CSB-PA002655LA01HU
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against BDNF. Recognizes BDNF from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

BDNF Antibody

1-CSB-PA05775A0Rb
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against BDNF. Recognizes BDNF from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

BDNF Antibody

1-CSB-PA616184
  • Ask for price
  • Ask for price
  • 100ul
  • 50ul
Description: A polyclonal antibody against BDNF. Recognizes BDNF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:10-1:50

Bdnf Antibody

1-CSB-PA16639A0Rb
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against Bdnf. Recognizes Bdnf from Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000

BDNF Antibody

GWB-2F6D6D 0.05 mg Ask for price

BDNF Antibody

GWB-A8C32F 0.1 mg Ask for price

BDNF Antibody

GWB-E773F2 0.1 mg Ask for price

BDNF Antibody

GWB-MP007G 50ug Ask for price

BDNF Antibody

F50934-0.08ML 0.08 ml
EUR 140.25
Description: BDNF is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this protein is reduced in both Alzheimer's and Huntington disease patients. This protein may play a role in the regulation of stress response and in the biology of mood disorders.

BDNF Antibody

F50934-0.4ML 0.4 ml
EUR 322.15
Description: BDNF is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this protein is reduced in both Alzheimer's and Huntington disease patients. This protein may play a role in the regulation of stress response and in the biology of mood disorders.

BDNF antibody

PAab10014 100 ug
EUR 463.2

BDNF Antibody

R30184 100 ug
EUR 356.15
Description: Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that includes NGF, NT3, and NT4. BDNF is a prosurvival factor induced by cortical neurons that is necessary for survival of striatal neurons in the brain. BDNF is expressed within peripheral ganglia and is not restricted to neuronal target fields. BDNF has been purified and shown to reduce the amount of naturally occurring neuronal cell death in portions of the peripheral nervous system.

BDNF Antibody

R31503 100 ug
EUR 356.15
Description: Brain-derived neurotrophic factor is a secreted protein that, in humans, is encoded by the BDNF gene. It is a member of the neurotrophin family of growth factors, which are related to the canonical nerve growth factor. BDNF is a prosurvival factor induced by cortical neurons that is necessary for survival of striatal neurons in the brain. It is expressed within peripheral ganglia and is not restricted to neuronal target fields. It has been purified and shown to reduce the amount of naturally occurring neuronal cell death in portions of the peripheral nervous system.

BDNF Antibody

R34016-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Brain-derived neurotrophic factor

Nori® Human BDNF ELISA Kit

GR111085 96-well
EUR 461

BDNF

E8ER130915 100ul
EUR 275
Description: Available in various conjugation types.

BDNF

cyt-207 2µg
EUR 60
Description: Recombinant Human Brain-Derived Neurotrophic Factor

BDNF

E8ET1606-42 100ul
EUR 275
Description: Available in various conjugation types.

BDNF

ant-128 0.5mg
EUR 275
Description: Mouse Anti Human Brain-Derived Neurotrophic Factor

BDNF

CH15000 100 ug
EUR 631.2

BDNF

CSB-CL002655HU 10 μg plasmid + 200μl Glycerol Ask for price

BDNF

GT41014 100 ug
EUR 546

BDNF

PR15020 5 ug
EUR 428.4

BDNF

PR27080 2 ug
EUR 229.2

BDNF

PR29001 2 ug
EUR 277.2

BDNF

MO15115 500 ug
EUR 1154.4

BDNF

P41014 100 ug Blocking Peptide
EUR 286.8

BDNF

PR27080-B each
EUR 184.5

BDNF

PA1014 100μg
EUR 260

BDNF

PA1014-M 100μg
EUR 290
Description: Polyclonal Antibodies Conjugated to Magnetic Beads

BDNF

PA1014-S 100μg
EUR 290
Description: Polyclonal Antibodies Conjugated to Sepharose Beads

BDNF (untagged)-Human brain-derived neurotrophic factor (BDNF), transcript variant 4

SC124461 10 µg Ask for price

BDNF (untagged)-Human brain-derived neurotrophic factor (BDNF), transcript variant 1

SC309453 10 µg Ask for price

BDNF (untagged)-Human brain-derived neurotrophic factor (BDNF), transcript variant 5

SC108977 10 µg Ask for price

BDNF (untagged)-Human brain-derived neurotrophic factor (BDNF), transcript variant 16

SC324838 10 µg Ask for price

BDNF (untagged)-Human brain-derived neurotrophic factor (BDNF), transcript variant 10

SC324839 10 µg Ask for price

Downregulation of lengthy noncoding RNA SNHG6 rescued propofol-induced cytotoxicity in human induced pluripotent stem cell-derived cardiomyocytes

 Background: Propofol (PPF) overdose is a uncommon however deadly situation, which can result in extreme cardiac failure. On this research, we established an in vitro PPF-induced cardiac cytotoxicity mannequin, and examine the purposeful function of lengthy non-coding RNA (lncRNA) small nucleolar RNA host gene 6 (SNHG6).

Strategies: Human induced pluripotent stem cell-derived cardiomyocytes (HiPSC-CMs) had been uncovered to PPF in vitro. PPF-induced cytotoxic results had been measured. PPF-induced SNHG6 expression change in HiPSC-CMs had been monitored by qRT-PCR. SNHG6 was downregulated in HiPSC-CMs to look at its function in PPF-induced cardiac cytotoxicity.

The expression of competing endogenous RNA (ceRNA) candidate of SNHG6, human microRNA-186-5p (hsa-miR-186-5p) was additionally investigated in PPF-exposed HiPSC-CMs. Capabilities of hsa-miR-186-5p had been additional investigated in PPF-exposed and SNHG6-downregulated HiPSC-CMs.

Outcomes: PPF induced important cytotoxicity, in addition to SNHG6 upregulation in HiPSC-CMs. SNHG6 downregulation had rescuing results on PPF-induced cardiac cytotoxicity. Twin-luciferase exercise assay confirmed that hsa-miR-186-5p was the ceRNA candidate of SNHG6. QRT-PCR confirmed hsa-miR-186-5p expression was reversely correlated with SNHG6 in PPF-exposed HiPSC-CMs. Suppressing hsa-miR-186-5p lowered the rescuing results of SNHG6-downregulation on PPF-induced cardiac cytotoxicity.

Conclusions: SNHG6/hsa-miR-186-5p can modulate PPF-induced cardiac cytotoxicity in HiPSC-CMs, and thus could also be a future drug goal to forestall PPF infusion syndrome.

Round RNA GLIS2 promotes colorectal most cancers cell motility through activation of the NF-κB pathway 

Round RNAs (circRNAs) are a newly found kind of organic molecule that belongs to the noncoding RNA household. Plentiful proof has proven that circRNAs are concerned within the development of varied cancers. Nevertheless, the actual features of circRNAs in colorectal most cancers (CRC) stay elusive. On this research, we investigated the differentially expressed circRNAs in three pairs of most cancers tissue and adjoining regular tissue of CRC.

We revealed that circGLIS2 expression was greater in CRC tissue and cell traces. Acquire-and-loss perform assays confirmed that circGLIS2 was concerned within the regulation of cell migration. Furthermore, overexpressing circGLIS2 in CRC cells activated the NF-κB pathway and induced pro-inflammatory chemokine manufacturing, which evoked tumor-associated irritation by recruiting leukocytes. In flip, when the most cancers cells had been uncovered to the supernatant of circGLIS2 overexpressed most cancers cells, they had been endowed with the flexibility of migration and chemokines manufacturing.

Moreover, the rescue assay confirmed that circGLIS2 activated NF-κB signaling and promoted cell migration by sponging miR-671. General, our research reveals that circGLIS2, performing as a possible oncogene, maintains the irregular activation state of the NF-κB signaling pathway through the miR-671 sponge mechanism in CRC cells. This research offers a scientific foundation for focusing on circGLIS2 in colorectal most cancers interventions.

The RNA binding protein FMR1 controls selective exosomal miRNA cargo loading throughout irritation 

  • Cells reply to inflammatory illness states by releasing exosomes containing extremely particular protein and RNA cargos, however how irritation alters cargo specificity and secretion of exosomes is unknown.
  • We present that will increase in exosome secretion induced by both viral an infection or LPS/ATP publicity consequence from inflammasome activation and subsequent caspase-1-dependent cleavage of the trafficking adaptor protein RILP.
  • This cleaved type of RILP promotes the motion of multivesicular our bodies towards the cell periphery and induces selective exosomal miRNA cargo loading. We’ve got recognized a standard brief sequence motif current in miRNAs which are selectively loaded into exosomes after RILP cleavage.
  • This motif binds the RNA binding protein FMR1 and directs miRNA loading into exosomes through interplay with elements of the ESCRT (endosomal sorting advanced required for transport) pathway. These outcomes point out that inflammasome-mediated RILP cleavage, and sequence-specific interactions between miRNAs and FMR1, play a big function in exosome cargo loading and enhanced secretion throughout mobile inflammatory responses.

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